Antifungal Azoles: A Comprehensive Survey of their by Ludwig Zirngibl

By Ludwig Zirngibl

Azoles are relevant elements in lots of medicines, taking part in a massive position within the struggle opposed to pores and skin illnesses and the secondary signs of AIDS. also they are utilized in the security of crops and in (heather, wool, fibres). This booklet examines the swift advancements during this box and serves as a instruction manual approximately their makes use of and functions.

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19 show activity against Staphylococcus and E. 110] In a similar group of 18 2 1-(Hydrogen-, alkyl-, aryl-, heterocyclyl-, arylalkyl-, heterocyclylalkyl-, ... 101. 113] Photostimulation of 4-nitrobenzyl chloride results in similar products in a classical SRN1-reaction. 117] Asymmetrically 3,5-disubstituted 4H-1,2,4-triazoles can be prepared from 1,3,4-oxadiazoles and benzylamine. 120] Triazolylmethyl-benzeneamines inhibit Aspergillus flavus, A. 121] but show low activity against Candida albicans, Penicillum spp.

However, no clear-cut relationships could be worked out with the QSAR methods of Hansch and of Free-Wilson, since some of the mathematical properties of the biological results lacked sufficient precision. Rank correlations are useful and confirmed the superiority of ortho-substitution for antimycotic acticity. 419] 40 2 1-(Hydrogen-, alkyl-, aryl-, heterocyclyl-, arylalkyl-, heterocyclylalkyl-, ... 430] Clotrimazole may serve as a novel antidiarrheal agent owing to its interference of K+ transport.

045]. 041] Other compounds with R = 4-ClC6H4 are weakly active against Candida albicans and with Az = Tri, moderately active against Candida sp. (C. glabrata, C. tropicalis, C. guillermondii, C. krusei, C. parapsilosis, C. 046] Another similar substance with Az = Tr, R = 4-(bromophenoxy)-2-chlorophenyl controls Venturia inaequalis and Erysiphe graminis. 12 shows superior activity against Botrytis cinerea on beans. 060] This is interpreted as a consequence of membrane perturbation of the fungus by the ionized and/or non-ionized imidazole compound, possibly via inhibition of membrane-bound enzymes.

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