By David A. Lightner
The booklet covers the totality of bilirubin (and heme from which bilirubin is derived biogenetically) the structural courting of bilirubin to its answer homes and metabolism and to phototherapy for the jaundiced baby - a standard clinical process used these days for reducing serum bilirubin, that's neurotoxic.
Read Online or Download Bilirubin: Jekyll and Hyde Pigment of Life: Pursuit of Its Structure Through Two World Wars to the New Millenium (Progress in the Chemistry of Organic Natural Products) PDF
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The ebook covers the totality of bilirubin (and heme from which bilirubin is derived biogenetically) the structural courting of bilirubin to its answer houses and metabolism and to phototherapy for the jaundiced infant - a typical clinical method used these days for decreasing serum bilirubin, that's neurotoxic.
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Additional resources for Bilirubin: Jekyll and Hyde Pigment of Life: Pursuit of Its Structure Through Two World Wars to the New Millenium (Progress in the Chemistry of Organic Natural Products)
Destructive distillation (calcination), which had served for centuries, was being abandoned as an analytical method and replaced by new approaches aimed at isolation of components in a state unchanged by the process of separation. The revolution in scientific thought and experimentation of the 18th century thus brought into the turbulent 19th a new perspective in organic chemistry, which was still steeped in “Vitalism” but poised to broaden into the realm of interconversion and synthesis in a laboratory environment.
10 It would seem that Berzelius could not have commented in as much depth on the non-pigmented components of bile in 1839 unless he had continued working on them before and during the 1830s. And although he was clearly responding to Liebig’s comments regarding the work of Demarçay, he was apparently not impressed or startled by Liebig’s comment to him in a letter of February 1837 regarding his student, Demarçay, to the effect that Demarçay’s then recent findings on bile seemed to overturn all previously accepted results.
8 Although never described as pure compounds, the yellow and green material behaved like what we now know as bilirubin and biliverdin. The pigments of bile notwithstanding, it was evident that bile was not composed of pigmented material alone but also contained fatty or soap-like components. Indeed, bile had long been considered to be a “soap”, and the soapy or lipid-like substances were attracting the attention of Gmelin, Berzelius, and other investigators, including Demarçay (63) and Loir (64, 65).