Biosensors for Health, Environment and Biosecurity by P. Serra

By P. Serra

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Work by Michaelson et al. (Michaelson et al. 1999) indicates a 96% survival rate if patients could be screened every three months. Thus, mortality in breast cancer patients could be reduced by increasing the frequency of screening. However this is not feasible presently due to the lack of cheap and reliable technologies that can screen breast cancer non-invasively. AlGaN/GaN High Electron Mobility Transistor Based Sensors for Bio-Application 41 Fig. 21. Time dependent current signal when exposing the HEMT to 1ng/ml and 10ng/ml KIM-1 in PBS buffer.

Figure 16 (bottom) shows a real time botulinum toxin detection in PBS buffer solution using the source and drain current change with constant bias of 500 mV. No current change can be seen with the addition of buffer solution around 100 seconds, showing the specificity and stability of the device. In clear contrast, the current change showed a rapid response in less than 5 seconds when target 1 ng/ml botulinum toxin was added to the surface. The abrupt current change due to the exposure of botulinum toxin in a buffer solution was stabilized after the botulinum toxin thoroughly diffused into the buffer solution.

2007, Park, Boo and Chung 2006). ZnO-based nano-materials are especially interesting due to their non-toxic properties, low cost of fabrication and favorable electrostatic interaction between ZnO and the GOx lever. However, the activity of GOx is highly dependent on the pH value of the solution (Pandey et al. 2007). The pH value of a typical healthy person is between 7 and 8. g. 20 (n=19) for the control subjects (Kouassi, Irudayaraj and McCarty 2005). To achieve accurate glucose concentration measurement with immobilized GOx, it is necessary to determine the pH value and glucose concentration with an integrated pH and glucose sensor.

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